Joan Challis asked me the following question in another discussion but I figured I'd spin off another discussion rather than hijack that one.
Joan asks :: hi ralph i have been searching the sayles of peel and my great grandad was claudius caesar sayle of 25 (also number 1) shore road peel and am wondering if back a ways they may have originated from elsewhere on the island
I checked Ancestry.com as you have and saw that Claudius was apparently born in Peel about 1836 although one of the census records did say he was born in Ireland.
My grandfather was born in Bride in 1849 and his father was born in Bride about 1796. I haven't tried to go back any further as I don't really have decent access to the old parish records plus my great grandfather was John Sayle, one of MANY named thusly!
Now in http://www.isle-of-man.com/cgi-bin/interests/genealogy/bulletin/index.pl?noframes;read=507334 Frances itemizes some counts of Sayle births from 1726-1750. Top of the list is 38 births in Andreas and Frances says "thus the breakout from their centre in Andreas down the west coast predates 1725."
So the origin of Sayle was in the north (I have read "Sayle is a North Manx name" which makes me laugh. It makes the IOM seem like a vast place). If you and I are related, and why not, then definitely it's from the 18th century. Your ancestors probably left Andreas after 1750 whereas my father left Bride nearly 150 years later.