There is a family that might fit:
John Caine md Elizabeth Creech 4 Jun 1842
1851 living in Maughold
1851 Maughold
, 01-05, 15, CAIN, John, Balldromma, Head, Married, 39, Labourer at, Braddan
, , , , , , , , I. Ore Mines
, 01-05, 15, CAIN, Elizabeth, Balldromma, Wife, Married, 28, , Santon
, 01-05, 15, CAIN, Wm, Balldromma, Son, , 4, Sunday S. Scholar, Maughold
, 01-05, 15, CAIN, John, Balldromma, Son, , 2, , Maughold
, 01-05, 15, CAIN, Margt, Balldromma, Daughter, , 13, , Maughold

In 1861 they are in Ramsey--I only have the index
Ramsey 1 107
1861 Ramsey
1 107
CAIN
John 45 b Braddan
Elizabeth 38 b Santan
John 12 b Ramsey
Agnes 5 b Ramsey
Daniel 10 b Ramsey
William 14 b Lezayre

1871 Index
Ramsey 1 124
CAINE
John 56 b Braddan
Elizabeth 47 b Braddan
Edward 10
Daniel 17
1881
, 3, 25, 148, CAIN, John, 52, College St., Head, Married, 66, Labourer, Braddan
, 3, 25, 148, CAIN, Elizabeth, 52, College St., Wife, Married, 58, , Santon
, 3, 25, 148, CAIN, Daniel, 52, College St., Son, Unmarried, 29, Masons Labourer, Maughold
, 3, 25, 148, CAIN, Edward, 52, College St., Son, , 19, Appt Ships Carpenter, Ramsey
, 3, 25, 148, CORKHILL, John R., 52, College St., Boarder, , 10, Scholar, Ramsey