I am not certain, but I believe Thomas Clague of Santon was the son of John Clague(1759-1834) and Catherine Kermode(1760-1833). They married in 1781, and lived at Ballacregga, Santon.
Children
Margaret m John Quiggin
Robert
William m Jane Gick
Henry m Margaret Cannel
Ann
John
Elizabeth
Ellenor m John Kneen
Thomas(1790-26 Oct 1873) m Esther Kneen(1792-21 Apr 1881)

There is some information in Thomas and Esther's Wills ref BM330 and BM 345 respectively. They are buried in Santon Graveyard.
Their children were
John 23 Oct 1814 (KR)
William 11 Aug 1816 (KR) m Jane Taggart 12 Jan 1860 (Malew)
Richard 17 Oct 1818 (KR)
Catherine 5 Nov 1820 (KR)
Thomas 22 Dec 1822 (KR) m Margaret Elizabeth Moore
Esther 8 Mar 1829 and 18 Mar 1831 (S) m John Collister 1853 Santon
Jane 19 Mar 1834 (S) m Charles Clague 30 Oct 1862 (Arbory)
Margaret 31 Jan 1834 (S) m Robert Cubbon 2 Aug 1866 (Arbory)
James
Robert

Other oddments:
Jane Clague is a housekeeper with niece Elizabeth Taggart in 1871 - a relative of Jane Taggart? Also, William and Jane are at 1 Goldie Terrace in Onchan in 1881, and William is a Bootmaker. William's son, William Paul Clague, an Accountant, is described as "of Castletown".

Margaret and Robert live at Ballaglonna, Arbory in 1881.

There is a reference to Margaret Watterson, wife of Edward, in Esther's Will - unresolved, and a reference to Ann, widow of Robert. This is presumably Anne Kelly formerly Kneale and therefore Robert's father Thomas Clague is indeed the same one whose daughter Esther married John Collister.

All Thomas/Margaret's children are christened in Castletown St Mary.
All except William Moore Clague(chr 3 Oct 1860 CSM) are mentioned in Mon. Inscrip. below.

Relevant Monumental Inscriptions
In loving memory of Jane, widow of the late William Clague, shoemaker, late of Douglas, who departed this life 27 February 1900, aged 75 years. Also Eleanor Jane, only daughter of the above, who departed this life 2 Oct 1905, aged 42 years.

In remembrance of William Clague of Douglas, shoemaker, who departed this life 26 August 1893, aged 77 years. Also William Paul Clague, accountant, son of the above, who departed this life November 13, 1893.
Sacred to the memory of Thomas Clague formerly of Arragon-Moar, who departed this life October 26, 1873, in the 84 years of his age. Also to the memory of Esther, wife of the above named Thomas Clague, who departed this life April 21, 1881, in the 90th year of her age.

In memory of Margaret Elizabeth Moore, wife of Thomas Clague of Arragon Moar, who died the 30 August 1895, aged 71 years. Also Thomas Samuel, son of the above Thomas Clague & of Margaret Elizabeth, his wife, who died the 12 January 1892, aged 25 years. And Margaret Alice, their daughter, who died the 14 May 1894, aged 25 years. And Catherine Christian, their daughter, who died 19 February 1897, age 32 years. Emily Esther died Dec 9, 1900, aged 38 years. Also the above named Thomas Clague who died October 18, 1912, in his 90th year.

In memory of Jane Clague alias Gick, wife of William Clague, who departed this life on the 13 October 1831, aged 26 years. Also their son, Thomas, who departed this life on the 5 March 1829, aged 6 months.

I hope these notes are of some help.