William DeMeza md MARGARET Killey 1 May 1864 Maughold

Per Manx Note Book they were in Ohio USA for 1880 census
US Census 1880
Ohio
Manx born
Louisa Jane b 1865 dau
Margaret b 1847 wife
William 1845 self

The old board info I have in my database, indicated that Demeza started out in Portugal, then went to England, then IOM.
Writer was descendant of William DeMeza

Said Fa William b 1801 and Jane b 1803 both in England.
Some of their children were b in Manchester

Perhaps you need to go to English records?

I don't have anything as to Jane's maiden name