The 1861 census has at 343 Stretford Road Hulme Manchester:-

James Wylde 43 Chemist and Dentist,London Middlesex
Mary 42 wife Lancashire Aston in Makerfield
Mary Cordelia 14 Hulme
Bertha 12
James Harold 9
Elias W.C. 8
Henry Frank 6
Kate 4mths
Florence 4mths

They are at the same address in 1881 but James at 73 appears to be visiting the I.o.Man in 1891.

How do you know William Henry is the son of James ?

Len Faragher