Sorry, the brothers are not in the Maughold records, and I don't have the Ramsey ones.
Quine was not a common name in Maughold, so I would guess that John Quine went to Ramsey from elsewhere, and that it was Ann Kneal who was from Maughold. Their Maughold marriage has only John Quine & Ann Kneal married 15 May 1742.
I can't see a burial for Ann in Maughold, so was probably in Ramsey.

Averil's suggestions look well worth following up.

Sue