I found John Cavendish and family in the 1850 census where John is listed as age 35, occupation black smith, place of birth as "Manx Man".
His wife, Mary, age 30
Children:
John, age 7
one unreadable beginning with Fr- and ending with -nd (does not appear to be Ferdinand), age 5
Mary E, age 3
Thomas, age 1

Wife and all children born in Ohio.

At the time of their census information was written, (6 Aug 1850), they were living in New Albany, Ohio, which is northeast of Columbus, Ohio.

Still searching for Eleanor Kissick.