Hi David

Sadly, it looks as though the William Craine in Lockport, Niagara, NY, wasn’t the same person as the Wm Craine who was a brother of Mary Ann and John Frederick:

From Find a Grave:

William H. Craine
Birth 2 Nov 1824
Michael, Michael, Isle of Man
Death 2 Nov 1899 (aged 75)
Niagara County, New York, USA
Burial Cold Springs Cemetery
Lockport, Niagara County, New York, USA

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and maybe this is the baptism of the Niagara Wm Craine from familysearch:
William Craine
Isle of Man Parish Registers
Event Type Christening
Event Date 10 Nov 1824
Event Place Michael, Isle of Man
Gender Male
Father's Name John Craine
Mother's Name Ann Quirk

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On the subject of Ancestry ---- yes, there’s a load of misinformation in many of the trees, but if you look for the grains of wheat and discard the chaff, it really is very useful.

Blair, have you thought about doing an Ancestry DNA test, and contacting a direct descendant of John Frederick Crane b 1832 with a suggestion that he/she might also like to do the same ?

Jean