IOM Parish Registers 1598-2009 show Hugh Cain marrying Esther Kilpack on 18 Nov 1820 in Andreas but England Marriages 1538-1973 and Isle of Man Marriages 1606-1911 show Hugh Cain marrying Esther Kissack on 18 Nov 1820 at Andreas. I am assuming that Kilpack has been misread as Kissack. Can you confirm surname?
1861 Census for the household shows a lodger with the name Kilpack. iMuseum have a baptism record for an unnamed female born in 1841 with parents Esther Kussack and Hugh Cain. Would this be Mira Cain's birth?