Hi Ken

If you put John Cain / Jane no surname into Familysearch over a wide time range around the 1745 you mention, there were surprisingly few couples having children----just Jane Lace in the 1730s and 1740s, Jane Cowin in the 1750s and 1760s, and Jane Lewin in the 1760s. But there was a John Cain/Jane Bridson couple having children in Malew in the 1760s and 1770s (patron submission marriage 4 Nov 1766 Malew.) Is this far too late for your couple, or could it have been at the late end of Jane Bridson's childbearing years ?

These baptisms are all extracted entries:

Results for any event 1741-1781, Isle of Man, British Isles
Father: John Cain, Mother: Jane Bridson
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International Genealogical Index / British Isles - 5
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1. THOMAS CAIN - International Genealogical Index
Gender: Male Christening: 23 APR 1769 Malew, Isle Of Man, England

2. ELIZTH CAIN - International Genealogical Index
Gender: Female Christening: 24 JAN 1768 Malew, Isle Of Man, England

3. CATH CAIN - International Genealogical Index
Gender: Female Christening: 16 DEC 1770 Malew, Isle Of Man, England

4. ESTHER CAIN - International Genealogical Index
Gender: Female Christening: 10 MAR 1776 Malew, Isle Of Man, England

5. ANN CAIN - International Genealogical Index
Gender: Female Christening: 13 DEC 1772 Malew, Isle Of Man, England

Jean C