Clive, thanks for the quick and helpful response. I had looked at the wills of both James Callow and his wife Isabel Callow als Kneale on line and discovered that while their female children were named neither Isabel nor his sister Catherine were referred to my married names -- thus no help in sorting out the two Isabels.
I lean towards Isabel daughter of James and Joney for the wife of John Kermeen. Isobel and John Kermeen had the following children (all bapt in Maughold) Jon, 1741; Catherine, 1742; James, 1744, Thomas, 1750; Isabel, 1753; Jane, 1758; Mary, 1762. Those are all from the IGI. There is one further child, Ann, who is not to be found in the IGI but whose name appears in her father's will of 1769 ( I am in the midst of transcribing and will have it put up on line) Tom Kermen attributes a further child -- Joney. Her name appears in Lawson's burial index July 13 1751 at Maughold. I have not been able to confirm that this Joney was an infant whose parents were John Kermeen and Isabel Callow.
The names I have found for the children of William Kermeen and Isabel Callow are: Margaret, 1741; William, 1743; Anne, 1748 (died as an infant); Thomas, 1747.
You will note that in John and Isabel's line the name of James (possibly Joney) and other names from James and Joney's family appear, while none of the names appear in William and Isabel's line. The question is how strong was the traditional naming pattern in the Isle of Man in the 18th century. Do you have any comments/