Lois -
I have located a James Kewley (c1783-1841) fruiterer & possibly hatter of E. London. May have been b. IOM. Wife was a Jane (possibly Quine) b. IOM c1777, d. 1869). Children possibly Elizabeth & William.
This Margaret Skillicorn was mentioned in James's will (PCC) as being a joint owner of a mortgage investment in E. London. She was squeezed onto the bottom of a census entry in 1851 "Margaret Skillicorne (?) Visitor Unm. 60 Income from ....(funds or land?) b. Isle of Man". Jane Kewley was also a visitor at the same address, Jane Kewley's former home at Shadwell High St., home of Alexander & Elizabeth Catner or Catnur. Jane could have been visiting her tenants, or more likely they were related.

Thanks