Hi, Viv
I haven't done much on the various children of Henry/Maria. There is a James Caine b Ballaugh 1845 in the Douglas 1881 census.
We know from 1861 census that James was a joiner.

1861 Michael
Ballarkenny
Maria Nelson head widow 52 annuitant b Lezayre (Maria Cottier Caine Nelson)
Alfred Nelson son 11 b Michael
Eliza Cain dau 17 b Ballaugh
James son 15 joiner app b Ballaugh
Thomas son 13 scholar b Ballaugh

Is this your James?
1881 Onchan
CAIN James 9 Adelaide Terr Head M 35 Master Builder Employ 8 Men 3 Boys Ballaugh IoM
Onchan CAIN Ester Isabell 9 Adelaide Terr Wife M 33 House Keeper Ballaugh IoM (Esther Elizabeth/Isabella Killip)
Onchan CAIN Henry Will. 9 Adelaide Terr Son U 7 Scholar Douglas IoM
Onchan CAIN James 9 Adelaide Terr Son U 6 Scholar Douglas IoM (James Oliver ch 6 Dec 1874)
Onchan CAIN John Ed. 9 Adelaide Terr Son - 5 Scholar Douglas IoM
Onchan CAIN Edric 9 Adelaide Terr Son - 3 --- Douglas IoM
Onchan MAC GILL Clara 9 Adelaide Terr Ser U 18 Sevant Domestic British Subj India

1891 Index
CAINE James 45 Douglas 4688 55 166
CAINE Esther J 43 Douglas 4688 55 166
CAINE Henry W 17 Douglas 4688 55 166
CAINE James O 16 Douglas 4688 55 166
CAINE John E 15 Douglas 4688 55 166
CAINE Edric 13 Douglas 4688 55 166
CAINE Winifred 2 Douglas 4688 55 166

1901 Index
CAINE James 55 Douglas 5303 27 27
CAINE Winifred 12 Douglas 5303 27 27

CAINE James O 26 Onchan 5302 93 240 The James Oliver Caine who was b 1874 and d 1940 was s/o James Caine & Esther Elizabeth Killip

CAINE Clara 24 Onchan 5302 93 240
CAINE Clara H 3 Onchan 5302 93 240
CAINE James O 1 Onchan 5302 93 240 James b 4 Dec 1899 Douglas s/o James O & Clara Annie Gill
CAINE Edrie 23 Onchan 5302 93 240

DBC
NR 19
In loving memory of
J O CAINE Burial Register says this is James Oliver
beloved husband of Marie CAINE
who died 9th Jan 1940 aged 65 years
Also of MARIE Have no idea who she is?????
widow of the above
who died 14th July 1958 aged 57 years

Have no idea what happened to Esther Eliz/Isa ?????????

DJD