A couple of points:
You are so correct, Frances, that it is absolutely necessary, in the 17th and 18th centuries, especially, to use the land records and wills, in addition to the parish records--and in cases where the parish records are incomplete, as they seem to be in most (all?) parishes, the land records, used in conjunction with the wills, are the only way to possibly piece together a family. I have not had as much experience with piecing together families as some of the others on the board, nor have I had any personal experience using information from the presentments, but I do know that in my own research, I would not have been able to make family connections without following the land holdings. And, in some cases, there are no land records to help... Then you're left with only being able to say "perhaps", or "possibly".
Another point, this one re Frank Trowbridge: it was apparently his mother, in the mid 1930s, who originally thought that Patrick had a wife Susan Crawford, not realizing that there were two Patrick Cains in South Carolina at the same time. (The other Patrick has been shown to be from Ireland, and eventually left South Carolina.) However many online trees still show Susan Crawford as a wife, with the Manx information added in.) Frank has tried, on various message boards, to make the correction, but either not everyone has read the messages, or they can't get their head around the need to revise the original compilation. I have some sympathy with this, as I've had to revise my thinking on several families, where subsequent findings have left my original ideas in a shambles.
To move on to the US side: I find it interesting that Patrick Cain settled in a Scots-Irish area of Virginia. Was there a connection, or sympathy, between the Manx and the Scots-Irish, that would have led a Manxman to this area?