there are 2 ann cains buried on same day (21 may 1767)in German - however I can't find a will for Ann cain als quirk - I suspect John married again but can't find his will naming children of 1st marriage - one possibility is a 2nd marr to cath maddrell - the will of 1777 John cain largydoo matches this but doesn't indicate any previous marr

German Burial Register
Ann als SHIMMIN als CRAIN bur 21 May 1767
Anne als QUIRK bur 21 May 1767

DJD