There are at least 2 John Caine/Ann Quirk duos in German in this time period

John Caine/Ann Quirk md 13 Feb 1747 Patrick
James ch 19 Feb 1748 German
Jane ch 13 Jan 1750--bur 21 Jun 1751 German
John ch 19 Jun 1755 German
Lenora ch 21 May 1758 German

Ann Quirk d 20 May 1758 bur 21 May 1758 1758-2 E d CAINE Ann QUIRK [bur ger 21 May 1758];d 20 may 1758;ch james,john,ann,leonora all ua next of kin philip cowley supv;husb john

There is a Philip Cowley md to a Bahee Quirk 1742 Patrick--maybe she is sister of this Ann?

John Caine/Ann Quirk md 14 Oct 1758 German
Philip ch 10 Jun 1759 German md Hester Mylevorry 21 May 1788
William ch 27 Jun 1764 German md Elinor Kewin 10 Nov 1787
Margaret ch 21 Jan 1767 German

This Ann Quirk Caine maybe bur 21 May 1767 German

In each family, John was left with young children and probably needed to remarry soon to have a mother for the children.

DJD