There is a great article on him on the Manx Notebook.
Malew Old Yard
Stones around church wall
#72
In memory of JOHN BRINE eldest son of THOMAS & Ann BRINE who died 8th December 1850 aged 12 years
In memory of THOMAS BRINE of Castletown architect who departed this life the 27 Jan 1840 aged 72 years

#73 Sarcophagus
In memory of THOMAS QUINE of Castletown, Architect who departed this life the 27th of January 1840 aged 73 years
In memory of JOHN BRINE Eldest son of THOMAS & ANN Brine who died ( ) aged 12 years (see above)

1841 Census Index
Castletown 1 2 7
BRINE
Ann 50
Emma 13
Louisa 15
Susan 20
Thomas 20

1851 Census
14 Crofts
Ann Brine head widow 60 proprietor of Houses b Castletown
Thomas son unmarried 32
Louisa daughter unmarried 27
Emma daughter unmarried 23
Jane Corrin servant 26 House Servant b Rushen