Hi Christine,
I would recommend starting here:
www.iomfhs.im/default.aspx?CategoryID=22
Go through the Kissack wills from that period and you might get lucky and find one that mentions a William in America.
You could also try Frances' Manx Notebook:
www.isle-of-man.com/manxnotebook/famhist/wills/index.htm
I assume you already know about the Kissack Genealogy site?
www.kissack.co.uk
Good luck,
Greg
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