!851 in 53 Boundary Place Liverpool:-

William Santley 65, Book Binder, Liverpool
Catherine, wife 67, Isle of Man
Anne 36, Liverpool daughter
Jane 23 ?, Liverpool daughter

1832 Liverpool Rent Book- see Liverpool and S.W.Lancs. FHS.

William Santley Bookbinder Roscoe Lane.
William Santley Bookseller Berry street.

Roscoe Lane runs into Berry street so it's probably the same person on a corner plot.

Frodsham is next to Runcorn so I guess there all part of the same string.
It appears that Thomas Santley married Ann Perry 1742 then Mary Johnson 1759 judging by the continuity of biblical names.

Most came to Liverpool although I see Shadrack married across the Mersey in Bebington Wirral.

The only Thomas C1786 was born to Moses and Ann Santley but he is noted in IGI as dying young.

Catherine Cowley C1784 will be difficult to distinguish in the Isle of Man.

Len Faragher