The Holme's family were bankers - 60 years of manx banking has:
http://www.ee.surrey.ac.uk/Contrib/manx/fulltext/sx1925/mb.htm - the family came to Island c.1800
Holmes' Bank above referred to (called also Douglas and Isle of Man Bank) opened in 1815 and closed in 1853, on the death of the last surviving partner. The Holmes' were fish-curers, which business they carried on at Derbyhaven. They were also shipowners and merchants in many other branches, and owned extensive property in the Island and in England. Their banking business was, for the time, very, considerable. Seeing that the sole owner and manager was at the close a blind man of seventy-five, it does not seem surprising that a long and difficult liquidation followed his death, but it does appear astonishing that the Bank deposits then reached, it is said, £200,000.

A Thomas Holmes grocer, baker, and spirit dealer is noted in Peel c.1823