Are you sure that John's (1837) father was called John and not James. James Caine married Sophia Kelly in Braddan 16 Mar. 1817 and subsequently had 8 children, all listed on IGI.
John married Margaret Kissack in Maughold where she lived on a 60 acre farm with her parents Ewan Kissack and Anne Skillicorn. Margaret had 4 siblings all listed on IGI. The farm was in Rhenab.