Tim, I’ve copied and pasted some records from Ancestry and familysearch which might be useful:

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Isabella Kelley

from Ohio, County Marriages
Name Charles B. Bukel
Event Type Marriage
Event Date 23 Dec 1852
Event Place Lawrence, Ohio, United States
Spouse's Name Isabella Kelley

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Name: Isabella Bickel
Maiden Name: Kelly
Birth Date: 26 Dec 1828
Death Date: 9 Aug 1899
Cemetery:Wyuka Cemetery
Burial or Cremation Place: Nebraska City, Otoe County, Nebraska, United States of America
Has Bio?: N
Spouse: Charles Bingley Bickel
Children: John K. Bickel
George R. Bickel

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The following Isabel Kelly is in the right place to be meeting and marrying Charles B Bickel 2 years later:

1850

Name: Isabel Kelly
Age: 22
Birth Year: abt 1828
Birthplace: England
Home in 1850: Upper, Lawrence, Ohio, USA
Gender: Female
Family Number: 251
Household Members: Name Age
John Kelly 25
Julia A Kelly 28
Isabel Kelly 22
Sarah Della 11

notes:
JK 25 labourer b England
JAK 28 b Ohio
IK 22 b England (is she John’s sister ?)
Sarah 11 b Ohio
John’s age should be 35----1880 census shows b 1815 and his grave shows birth date 3 Oct 1814

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1860

Ancestry’s transcription:
Name: Isabelle Bickle
Age: 30
Birth Year: abt 1830
Gender: Female
Birth Place: Isle of Man
Home in 1860:Nodaway ,Nodaway , Missouri
Post Office: Graham
Dwelling Number: 862
Family Number: 769
Occupation: Housekeeper
Household Members: Name Age
Charles Bickle 34
Isabelle Bickle 30
Mary Bickle 6
John Bickle 5
Adelbert Bickle 2
Charles Bickle 5/12

CB 34 master brick mason b Ohio

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1870
Nebraska City

Name Age
C B Bickel
J Bickel
M C Bickel
J R Bickel
A Bickel
C C Bickel
J B Bickel
G R Bickel

C B Bickel brick mason b Ohio
J Bickel 41 female b England

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Then I looked for the John Kelly / Julia A Kelly couple who were with Isabella in Lawrence in 1850:
John Kelly
United States Census, 1880
Other information in the record of John Kelly
from United States Census, 1880
Name John Kelly
Event Type Census
Event Date 1880
Event Place Ironton, Lawrence, Ohio, United States
Gender Male
Age 65
Marital Status Married
Occupation Preacher
Relationship to Head of Household Self
Relationship to Head of Household (Original) Self
Birth Year (Estimated) 1815
Birthplace Isle of Man
Father's Birthplace Isle of Man
Mother's Birthplace Isle of Man
Sheet Letter B
Sheet Number 173
Person Number 0
Volume 1

Household Role Age Birthplace
John Kelly Self M 65 Isle of Man
Julia A Kelly Julia A Kelly Wife F 58 Ohio, United States
Mary Treket Mary Treket Other F 19 Kentucky, United States
Ella Lautre Ella Lautre Other F 8 Ohio, United States

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Name: Rev John Kelly
Birth Date: 3 Oct 1814
Death Date: 12 Apr 1888
Cemetery: Woodland Cemetery
Burial or Cremation Place: Ironton, Lawrence County, Ohio, United States of America
Has Bio?: N
Spouse: Julia Ann Kelly

Inscription shows “native of the Isle of Man”

Julia Ann nee Hall b 10 Feb 1822. died 14 Aug 1905

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The birth dates of this John and your Isabella are consistent with John and Isabella, children of Thomas Kelly and Cath Quirk, if you allow for the possibility that Isabella “lost” a couple of years as she went through life.

Jean C