Just to tidy up a mistake in your birth year for Ellen J Caley--- in your message you have her dates as 1854-1960, making her age 106 at death and age 52 when she gave birth to Margaret Louisa Nightingale.

Below are the Ellen/Eleanor Caley entries in the 1871 IOM census:
CALEY Eleanor J 17 Bride 5773 9 15
CALEY Eleanor 16 Lezayre 5773 38 15
CALEY Eleanor 14 Ballaugh 5772 91 51
CALEY Eleanor 12 Douglas 5776 5 36
CALEY Ellen 9 Ramsey 5773 174 183
CALEY Eleanor 6 Ramsey 5773 160 22
CALEY Eleanor C 4 Douglas 5775 87 163
CALEY Eleanor J 6 mos Ramsey 5773 155 166

so your Ellen J Caley is the 6 month old, not the 17 yr old.

I've copied part of a message from the Ancestry site which will help others to find your Manx connections:

1910 Ohio census:

Name: Margaret L Nightingale
Birthplace: Ohio
Relationship to Head of Household: Daughter
Residence: Warrensville, Cuyahoga, Ohio
Marital Status: Single
Race : White
Gender: Female
Immigration Year:
Father's Birthplace: England
Mother's Birthplace: England
Family Number: 9
Page Number: 1
Household Gender Age Birthplace
SELF William H Nightingale M 70y England
WIFE Ellen J Nightingale F 39y England
DAU May J Nightingale F 10y Ohio
DAU Margaret L Nightingale F 3y Ohio

**********

For the benefit of anyone who might be able to help find living descendants on the IOM of your Caley and Joughin lines:

Marriage of Ellen J Caley's parents in Liverpool (Ancestry's transcription):

Liverpool, Lancashire, England, Marriages and Banns, 1813-1921
about Margaret Joughin
Name: Margaret Joughin
Birth Year: abt 1842
Age: 27
Marriage Date: 12 Jul 1869
Parish: Walton On The Hill St Thomas
Spouse's Name: William Caley
Father's Name: William Joughin
Spouse Father's Name: William Caley

Image shows:
William Caley/23/bachelor/farmer/173 Beaufort St/father William Caley, farmer.
Margaret Joughin/27/spinster/173 Beaufort St/father William Joughin, farmer.
Witnesses: William Craine and Annie Craine.

*****

Jean C