I have just found from another page on this website a reference to one of my great great grandmothers.
www.isle-of-man.com/manxnotebook/methdism/curry/p6.htm
entitled The Story of Primitive Methodism in the Isle of Man. By Rev. W. CURRY.

' By the. sheer weight of his goodness Mr. Ducker gained great influence, and when, on his invitation, our preachers went to Newtown to conduct services in his house, several of the young men were converted. Among others were T. Kinnish, W and T. Keig, Paul Faragher, and the McNeil brothers, to which family belonged the mother of Rev. F. N. Shimmin and the wife of Mr. W. Proctor.
The need for a chapel arose with the growing Society, and so the McNeil brothers went to their father, a farmer who farmed his own land, and asked for a plot on which to build a chapel. The father, struck with the earnestness of the lads, at once offered to sell them a site for five shillings. In a short time the ground was cleared and a little sanctuary built, mostly by free labour and given material. That was in the year 1827,'

Rev. F. N. Shimmin was my Great grandfather and we knew his mother married a McNeil. By following the link to the Newtown chapel
www.isle-of-man.com/manxnotebook/methdism/chapels/newtown.htm
It seems they spelled their name as McKneale, or possibly that and Kneale:
William Knowles preacher
Thomas McKneale, Croit Kneale/Santan
John Kneale, Douglas

Is it likely that Thomas McKneale and John Kneale are the Mcneil brothers mentioned in the chapel history? Or would it be only Thomas McKneale who must surely be a son of Issac?
members.shaw.ca/GenWebs/index.html
discusses one of Isaac's daughters
Any other info on this family line gratefully received. Thanks
Desmond