Thanks for your help again, Averill.

I should have added, to my litany of why William Caine is so confusing to me, is that there were a multitude of William Cain/Caines in Cuyahoga County by 1850:

Two of them were married to Margarets. (And I can’t find any definitive connection which will tell me their surnames – Your identification of Margaret Duggan looks pretty good, but, as I said, there are still some inconsistencues that worry me.) To continue with the William Caines,

there was one William married to Christian Caine,

one married to Eleanor Caine,

one married to Jane Caley.

Also a William married to Judith Corlett, (That William died before the 1850 census).

That said, I am pretty sure that the William and Margaret buried in Woodland are from the following family:

William H. Caine family of Warrensville:

William H. Caine (William Caine - ) was born about 1800, and died in Warrensville December 7, 1863, age 63. He married Margaret _____. She was born about 1808-20, and died of cholera, in Warrensville, August 20, 1862, age 54. (Woodland Cemetery Interments, Section 30, Lot 150)

Assuming their daughters Charlotte, Matilda, and Mary immigrated with her parents, William and Margaret Caine came to Warrensville in 1840. (Doesn't necessarily mean they immigrated in 1840)

[Genealogical Data Relating to Women in the Western Reserve before 1840 ( or born there before 1850), Collected and compiled by the Women’s Department, Cleveland Centennial Commision. FHL film 1009031. (Warrensville):
Mrs. _____ Gawne, Charlotte Caine 1840, last res Cleveland
Mrs. William Callow, Matilda Caine, 1840, last res. Memphis
Mrs. Joshua Thomas, Mary Caine, Cleveland, last res Cleveland]

1840 Warrensville census Wm Kane 1st: 2 m ales under 5 (James, George); 1 m ale 5-10 (John); 1 m ale 10-15 (who?); 1 m ale 30-40 (William); 1 fem ale 5-10 (Mary Ann); 1 fem ale 20-30 (Margaret)

1850 Warrensville census # 3162: Wm Caine 50 farmer IOM; Margaret 30 IOM; Mary Ann 19 Ohio; John 17 Ohio; James 13 Ohio; George 12 Ohio; Charlotte 10 Ohio; Matilda 6 Ohio; Albert 3 Ohio

1860 Warrensville census # 283: Wm. H. Caine 59 farmer IOM: Margaret 59 IOM; James 24 builder Ohio; George 22 engineer Ohio; Charlotte 19 Ohio; Matilda 16 Ohio; Albert 13 Ohio; Almira 9 Ohio.

Children of Margaret _____ and William H. Caine: born in Ohio

i. son Caine born 1825-1830.

ii. Mary Ann Caine was born about 1831. She married Joshua Thomas.

iii. John J. Caine was born about 1833, and died of heart disease, June 22, 1879, age 45. [Woodland Cemetery Interments, Section 30, Lot 147]

iv. James Caine was born about 1837.

v. George Caine was born about 1839. He may be the George Cain who died November 7, 1909, age 69 yr. [Cleveland Public Library Necrology File : “November 10, 1909; Cain-George, Sunday evening, November 7, aged 69 years. Funeral services at his late residence, 1296 Brockley, ave., Lakewood, Wednesday Nov. 10, at 1 o'clock standard. Interment at Riverside.”]

vi. Charlotte Caine was born about 1840. Charlotte Caine Gawne, wife of William Gawne, died July 5, 1905 in her 63rd year. Charlotte and William Gawne were married in Cuyahoga County, February 1, 1870. William Gawne died of nephritis, in Cleveland, September 23, 1913, age 73. Woodland Cemetery Interments: Section 30, Lot 150.

+ vii. Matilda Caine was born about 1844, and died January 11, 1913.[Woodland Cemetery Interments: Section 30, Lot 147] She married, in Cuyahoga County, December 4, 1870, William J. Callow. William and Tillie Callow lived in Van Wert County, Ohio. Children: Bessie M.; Dortha A.; Lloyd E.; Elva Lucille; Deloria E.

viii. Albert Caine was born about 1847.

ix. Almira Caine was born about 1851, and died of consumption, in Warrensville, June 23, 1861, age 10. [Woodland Cemetery Interments: Section 30, Lot 147]