I haven't looked at these Caine lines for years.
Looking at what Viv has noted and thanks to JC for 1861 and 1871 census info, it would seem that the Margaret Caine who married #1 Robert Quiggin and #2 Charles Quayle may instead be the daughter of Thomas Caine, weaver, Braddan & Margaret Corlett

The marriage of Robert Quiggin & Margaret Caine
Robert Quiggin full age bachelor Farmer Ballacrink father Thos
Quiggin farmer and Margaret Cain full age spinster Ballacrink father
Thomas Cain WEAVER married by W. Drury Vicar. This marriage was
solemnized by Robert Quiggin and Margaret Quiggin late Cain her x Mark.

Thomas Caine/Isabella Cannell was a TAILOR

Viv's Margaret who md Robert Thompson might very well be the d/o Thomas Caine & Isabella Cannell.

It would help to see the marriage register of Robert Thompson and Margaret Caine
Viv do you have that?

Donna