Hi, Pat
Anymore when I have a ? my first stop is Frances' Manx Note Book
The short answer is YES

KANEEN, contracted from Mac Cianain, 'Cianan's son,' (Cianan is a diminutive of Cian, which is itself a diminutive of ci, 'to weep.')

' CIANAN, Bishop of Doimhliag died,' A.D. 488.*

Compare (Irish) KEENAN (Gaelic) MAC KINNON.

KYNYNE [1422], KENEEN [1666], KENEN [1676], CANEEN [1729], KANEEN [1740], KENAN [1783].

A purely Manx name. it is almost confined to the parishes of Andreas and Jurby. Andreas (vc), Jurby (c), elsewhere (u).

* Four Mast., Vol. I., P. 153.

KNEEN, probably also a contractionof Mac Cianain. In our early documents it seems to be confused with NEVYN or NEVYNE. Andrew John NEVYN is one of the 24 Keys in 1417, while Jenkin M'NYNE in 1429 is as called Jenkine MAC NEVYNE in 1430.If it is a corruption of NEVYN, which is common in Scotland at the present day in the form NIVEN, it will have quite a different origin : from (Gaelic) Naomh, 'a saint.'

It is a purely Manx name.

MAC NYNE [1429], KNEENE [1504], KNEEN [1598].

Bride (vc), Ballaugh, Marown, Andreas, Lezayre, German, Santon, Rushen (c), elsewhere (u).

The following surnames occurring in the Isle of Man before the 17th century derive from the names of places in Lancashire, where some of them can be found at home so far back as the 13th century. Those italicised are still extant in the Island, though it is possible that some of them may have re-entered later.

Aghton, Alcar, Aystogh or Ayscough, Bradshagh, Byllinge, Burscough, Crosse, Assheton, Bootle, Coupe, Gremshawe, Heywood, Haliwell, Halsall, Holland, Hendull, Ince, KENYON, Lathom, Litherland, Langtre, Marsden, Prescott, Preston, Parr, Radcliffe, Rushton, Samlesbury (now Sansbury), Shakerley or Shakelady, Standish, Ughtynton (Oughtrington is just over the Cheshire border), and Worthington. Other early family names which are also English place- names are Ballard, Birmingham, Breden, Bydcrosse, Colcat or Calcott, Coupeland, Cotynghin, Creetch, Hampton, Iveno, Kent, Lake, Lecke,Haworth, Huddlestone Hartle, Higham, Moore, Fryssington, Sale (Sayle), Stanley, Twynham, Whetstones and Whinrowe. As Creetch may be of native growth it will be referred to again. Of the rest, many now extinct have left footprints in Manx soil as elements in land-names.

If you put Kaneen and Kenyon Isle of Man into google you will see several instances where Kaneen and Kenyon were used interchangeably.

DJD